Mesostabyl Ampoules - Polyunsaturated Phosphatidyl Choline

Belongs to the group of drugs that stimulate the breakdown, mobilisation and elimination of lipids.

Properties of the product

• In the organism, lipoproteins are responsible for transporting lipids to the target tissues.
• Their structure is adapted for the transport of lipids in plasma and formed by a hydrophile covering and a hydrophobe nucleus, thereby enabling the movement of lipids, both of endogenous and exogenous origin, for use.
• Polyunsaturated phosphatidyl choline is a choline-base phospholipid containing 80% linoleic acid, 15% oleic acid and 5% linolenic acid.
• It has anti-cholesterolaemiant action (by increasing lecithin-cholesterol-acyl-transferase activity), hypotriglyceridaemiant action (by lipase activation and reducing TGC synthesis) and reduces plasmatic viscosity.
  

Use in Mesotherapy

• MAGGIORI observed that when polyunsaturated phosphatidyl choline was orally administered to hypercholesterolaemic patients it not only improved lipid levels in plasma but also the xanthomas and xanthelasmas which occasionally coexist with dyslipaemia. This led to the idea of the mesotherapeutic use of the medication in patients affected by xanthelasmas, irrespective of whether they had normal or high levels of cholesterol.
• The protocol consists of the intra-lesional injection of polyunsaturated phosphatyl choline using an insulin syringe with a 13 mm-long, 30G needle . The needle should be introduced tangentially into the lesion and the product injected in a retrograde manner, i.e. as the needle is extracted.
• The injection causes a burning sensation that persists for more or less an hour.
• Despite the disagreeable sensation, MAGGIORI advises against combining phosphatidyl choline with local anaesthetics as it produces a notable decrease in the medication's activity. It is best to warn the patient of this dysaesthesia before beginning the session.
• The injection may be repeated weekly and 4 to 8 sessions tend to prove sufficient, depending on the age of the lesion, its extension and the coexistence of dyslipaemias, in which case you can rely on the complementary oral or intramuscular administration of polyunsaturated phosphatidyl choline (1 cc, 1 or 2 times a week).